MovDisordV3, France, Analysis, bibRecord, 000223

Adverse drug reactions to dopamine agonists: A comparative study in the french pharmacovigilance database

Identifieur interne : 000223 ( France/Analysis ); précédent : 000222; suivant : 000224

Adverse drug reactions to dopamine agonists: A comparative study in the french pharmacovigilance database

Auteurs : Santiago Perez-Lloret [France] ; Emmanuelle Bondon-Guitton [France] ; Olivier Rascol [France] ; Jean-Louis Montastruc [France]

Source :

Movement Disorders [ 0885-3185 ] ; 2010-09-15.

RBID : ISTEX:E1381185C79666F103D60BB6AB0F2C457243EB44

Descripteurs français

Wicri :
- geographic : France.

English descriptors

KwdEn :
- Adverse Drug Reaction Reporting Systems, Databases, Factual, Dopamine Agonists (adverse effects), France, Humans, Levodopa (adverse effects), Odds Ratio, adverse drug reactions, apomorphine, bromocriptine, dopamine agonists, pergolide, pharmacovigilance, pramipexole, ropinirole.
MESH :
- chemical , adverse effects : Dopamine Agonists, Levodopa.
- geographic : France.
- Adverse Drug Reaction Reporting Systems, Databases, Factual, Humans, Odds Ratio.

Abstract

Pharmacodynamical differences between dopamine agonists (DAs) suggest differences in their adverse drug reactions (ADRs) profile. In this study, frequencies of ADR to DAs or levodopa reports in the French Pharmacovigilance Database were explored. Reports occurring between January 1, 1984 and December 31, 2008 were selected (2,189 for DAs and 1,315 for levodopa). The numbers of ADRs by system organ class were compared using ropinirole as a reference. Diurnal somnolence was less frequently reported with all DAs when compared with ropinirole (P < 0.001). Impulse control disorders (ICDs) were more frequently reported with pramipexole (P < 0.001). Significant difference was found among DAs in the frequency of confusion or disorientation (P < 0.001), nausea and vomiting (P < 0.05), or edemas (P < 0.001). No difference among DAs was observed in the frequency of hallucination or arterial hypotension ADR reports (P = 0.3 and P = 0.1). Pleural effusions were more frequently reported with pergolide or bromocriptine (P < 0.001). Somnolence or ICD reports were less frequent with levodopa, whereas confusion was more frequently reported. In summary, our data show significant differences in the kind of ADRs reported for each DA. © 2010 Movement Disorder Society.

Url:

https://api.istex.fr/document/E1381185C79666F103D60BB6AB0F2C457243EB44/fulltext/pdf

DOI: 10.1002/mds.23204

Affiliations:

Links to Exploration step

ISTEX:E1381185C79666F103D60BB6AB0F2C457243EB44

Le document en format XML

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<front><div type="abstract" xml:lang="en">Pharmacodynamical differences between dopamine agonists (DAs) suggest differences in their adverse drug reactions (ADRs) profile. In this study, frequencies of ADR to DAs or levodopa reports in the French Pharmacovigilance Database were explored. Reports occurring between January 1, 1984 and December 31, 2008 were selected (2,189 for DAs and 1,315 for levodopa). The numbers of ADRs by system organ class were compared using ropinirole as a reference. Diurnal somnolence was less frequently reported with all DAs when compared with ropinirole (P < 0.001). Impulse control disorders (ICDs) were more frequently reported with pramipexole (P < 0.001). Significant difference was found among DAs in the frequency of confusion or disorientation (P < 0.001), nausea and vomiting (P < 0.05), or edemas (P < 0.001). No difference among DAs was observed in the frequency of hallucination or arterial hypotension ADR reports (P = 0.3 and P = 0.1). Pleural effusions were more frequently reported with pergolide or bromocriptine (P < 0.001). Somnolence or ICD reports were less frequent with levodopa, whereas confusion was more frequently reported. In summary, our data show significant differences in the kind of ADRs reported for each DA. © 2010 Movement Disorder Society.</div>
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Movement Disorders (revue)

Adverse drug reactions to dopamine agonists: A comparative study in the french pharmacovigilance database

Adverse drug reactions to dopamine agonists: A comparative study in the french pharmacovigilance database

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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